To create autoresponders in Plesk, you can follow these steps:

Step 1: Log in to your Plesk control panel using your administrator credentials.

Step 2: Once logged in, navigate to the "Mail" tab or section. This section is typically located in the left-hand sidebar or under the "Domains" category.

Step 3: In the Mail section, you should see a list of domains or email addresses. Locate the domain or email account for which you want to create an autoresponder and click on it.

Step 4: Inside the domain or email account settings, look for an option called "Autoresponders" or "Automatic Replies". Click on it.

Step 5: In the Autoresponders section, click on the "Add New Autoresponder" button.

Step 6: Configure the autoresponder settings, including:

From: Specify the sender's name or email address that will appear in the autoresponder message.

Subject: Enter the subject of the autoresponder message.

Message: Compose the content of the autoresponder message, which will be sent as a reply to incoming emails.

Start and End dates: Optionally set a specific time period during which the autoresponder will be active.

Step 7: Save the settings or apply the new autoresponder.

Step 8: Test the autoresponder by sending an email to the associated email address to verify that it functions as intended.

You can create multiple autoresponders for different email accounts or domains by repeating these steps as needed.

Please note that the availability and specific steps may vary depending on the version of Plesk you are using. If you encounter any issues or need further assistance, it's recommended to consult Plesk's documentation or contact our support team.